Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.
نویسندگان
چکیده
منابع مشابه
Simulation of Major Histocompatibility Complex (MHC) Structure and Peptide Loading into an MHC Binding Pocket with Teachers’Hands
Molecular understanding of three-dimensional (3D) peptide: MHC models require both basic knowledge of computational modeling and skilled visual perception, which are not possessed by all students. The present model aims to simulate MHC molecular structure with the hands and make a profound impression on the students.
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BACKGROUND Class II major histocompatibility complex (MHC) proteins are cell surface glycoproteins that bind peptides and present them to T cells as part of the mechanism for detecting and responding to foreign material in the body. The peptide-binding activity exhibits allele-specific preferences for particular sidechains at some positions, although the structural basis of these preferences is...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1990
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1990.tb08304.x